One-Pot Synthesis of Chiral Dihydrobenzofuran Framework via Rh/Pd Catalysis
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A one-pot synthesis of the chiral dihydrobenzofuran framework is described. The method utilizes Rh-catalyzed asymmetric ring opening (ARO) and Pd-catalyzed C–O coupling to furnish the product in excellent enantioselectivity without isolation of intermediates. Systematic metal–ligand studies were carried out to investigate the compatibility of each catalytic system using product enantiopurity as an indicator.
创建时间：
2016-02-20
