Non-B DNA, particularly G-quadruplex motifs, act as genomic beacons for HIV-1 integration in latently infected cells.

Elimination of the latent HIV-1 reservoir is essential for eradication of the virusfrom the body. The integration sites of these latent proviruses have been shown to playcritical roles in clonal expansion, persistence and reactivation of latent proviruses. To better understand the local genomic environment surrounding HIV-1 proviruses and its contribution to latency, we characterized integration site datasets from cells.