Model input parameters: mother-to-child transmission risks.

Data given as base-case value [references] (range for sensitivity analysis) [references].aAntenatal ZDV reflects the antenatal component of the Option A regimen for women who are not eligible for ART. Per WHO 2010 PMTCT guidelines, the intrapartum sdNVP and 7-d postnatal ZDV/lamivudine “tail” components of the Option A regimen may be omitted if a woman receives>4 wk of antenatal ZDV. The cited transmission risks reflect a range of antenatal ZDV treatment durations, as well as studies both including and excluding the sdNVP and ZDV/lamivudine components. The Pediatric AIDS Clinical Trials Group Protocol 076 study [96] was conducted in a replacement-fed population. However, this study demonstrated MTCT risks at the upper bound of the published range, reducing concern for underestimation of early postpartum MTCT risk, and thus was used in the “highest risk” scenario.EBF, exclusive breastfeeding (in first 6 mo of life, followed by mixed breastfeeding); MBF, mixed breastfeeding; n/a, not applicable.