SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

The plasma membrane transport protein SLC6A12 (BGT-1) mediates the uptake of GABA (gamma-aminobutyrate) and betaine and, less efficiently, of diminobutyrate (DABA) and beta-alanine. Together with each amino acid molecule, 3 sodium ions and 2 chloride ions are taken up. In the body, SLC6A12 is expressed in the proximal tubules of the kidney and cells of the central nervous system (Rasola et al. 1995; Matskevitch et al. 1999).

质膜转运蛋白SLC6A12（BGT-1）介导γ-氨基丁酸（GABA）和甜菜碱的摄取，以及相对不高效的二丁酸（DABA）和β-丙氨酸的摄取。与每个氨基酸分子一起，它还会摄取3个钠离子和2个氯离子。在人体中，SLC6A12在肾脏近端肾小管和中央神经系统的细胞中表达（Rasola等，1995年；Matskevitch等，1999年）。