Control of Embryonic Stem Cell State by Mediator and Cohesin (Illumina ChIP-Seq data)
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
The key transcription factors that control the embryonic stem cell gene expression program have been identified, but how they function to implement this program is not well understood. While screening for genes essential for maintenance of ES cell state, we identified many components of the Mediator and Cohesin complexes. Mediator and Cohesin were found to physically and functionally connect the enhancers and core promoters of active genes. An ES cell Mediator complex was found to copurify with Cohesin and its loading factor Nipbl, and normal levels of these proteins were essential for expression of the genes they occupy and for maintenance of ES cell state.
提供机构：
Whitehead Institute for Biomedical Research
创建时间：
2022-02-20
