Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.
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Crystal structure of beta-secretase bound to a potent and highly selective inhibitor. Descriptor: Beta-secretase 1, N~2~-[(2R,4S,5S)-5-{[N-{[(3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHOXY]CARBONYL}-3-(METHYLSULFONYL)-L-ALANYL]AMINO}-4-HYDROXY-2,7-DIMETHYLOCTANOYL]-N-ISOBUTYL-L-VALINAMIDE Authors: Hong, L, Ghosh, A, Tang, J. Deposit date: 2006-03-05 Release date: 2006-04-25 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors. J.Am.Chem.Soc., 128, 2006
创建时间：
2006-03-05
