BN大鼠

是近交系大鼠，1930年Wistar研究所的King在野外捕获的野生大鼠，并由King和Aptekman维持繁育，其中一个大鼠品系发生褐色突变，1958年Silvers和Billingham利用它们进行兄妹交配并进行组织相容性选择，2002年中国药品生物制品检定所从日本引入饲养，被毛为褐色，对实验性过敏性脑脊髓炎及自身免疫性复合型肾小球肾炎有抗性，30%先天性高血压，31月龄大鼠心内膜疾病发生率7%，上皮肿瘤发生率，雄性28%，雌性2%。输尿管肿瘤发生率，雄性6%，雌性20%。雄性膀胱自发癌发生率为35%，胰腺肿瘤为15%。主要用于肿瘤学，器官移植，药理学，视网膜退行性等研究和一些检定工作。This is an inbred rat strain. The founding wild-caught rats were collected by King from the wild in 1930 under the Wistar Institute, and were subsequently maintained and bred by King and Aptekman. A brown mutation emerged in one of the rat sublines. In 1958, Silvers and Billingham conducted brother-sister mating and histocompatibility selection on these rats. In 2002, the National Institutes for Food and Drug Control, China imported this strain from Japan for breeding. This strain has a brown coat. It exhibits resistance to experimental allergic encephalomyelitis (EAE) and autoimmune complex glomerulonephritis. Approximately 30% of the individuals in this strain present congenital hypertension. For 31-month-old rats, the incidence rate of endocardial disease is 7%. The incidence rates of epithelial tumors are 28% in males and 2% in females, respectively. For ureteral tumors, the incidence rates are 6% in males and 20% in females. The incidence rate of spontaneous bladder carcinoma in males is 35%, while that of pancreatic tumors is 15%. This strain is primarily utilized for research in oncology, organ transplantation, pharmacology, retinal degenerative diseases, as well as various validation and qualification assays.

搜集汇总

背景与挑战

背景概述

BN大鼠是一种近交系实验动物，具有明确的遗传背景和疾病表型，对实验性过敏性脑脊髓炎及自身免疫性复合型肾小球肾炎有抗性，同时表现出较高的先天性高血压、上皮肿瘤等发生率，广泛应用于肿瘤学、器官移植、药理学及视网膜退行性研究。