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Molecular basis of nuclear mRNA recognition and packaging

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NIAID Data Ecosystem2026-03-14 收录
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https://www.omicsdi.org/dataset/jpost/PXD031755
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Newly made messenger RNAs are processed and packaged into compact ribonucleoprotein complexes (mRNPs) and recognized by the essential transcription-export complex (TREX) for nuclear export. However, the mechanisms of mRNP recognition, compaction, and three-dimensional organization are poorly understood. Here we perform crosslinking MS on Sulfo-SDA crosslinked endogenous ribonucleoprotein complexes (mRNPs). These have been enriched through a pulldown of THOC1-3C-GFP.
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2023-01-31
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