Impact of triphenyl phosphate on sperm quality reduction: evidence from human, mice and cells

In this study, we identified that reduced T production in Leydig cells after TPhP exposure was attributed to impaired cholesterol metabolism. Collectively, these data indicated that TPhP exposure could reduce male reproductive quality, which provided insights into the adverse effects of TPhP on human reproductive health and also provided a basis for the formulation of policy on TPhP usage by relevant government agencies. To investigate the key events in mouse primary Leydig cells after TPhP or DPhP exposure, RNA-seq was performed to find the differentially expressed genes.