Supplementary Material for: Synchronous urinary bladder urothelial carcinoma and transitional cell carcinoma of the ovary: case report

Transitional cell carcinoma (TCC) of ovary is a rare subtype of epithelial ovarian tumours defined as a tumour composed of epithelial elements histologically resembling urothelium and its neoplasms. Ovarian metastases from primary urinary tract carcinomas are rare. The differential diagnosis of primary transitional cell carcinoma (TCC) of the ovary versus metastatic bladder TCC is challenging because of histological similarity. We present the case of a 49-year-old premenopausal woman who was initially diagnosed with non-invasive papillary urothelial carcinoma of bladder (NIPUC) and after two years with a synchronous TCC of the ovary while being investigated for suspected relapse. She underwent a radical cystectomy, total hysterectomy, bilateral salpingo-oopharectomy and pelvic lymph node dissection. The final diagnosis of synchronous NIPUC of the bladder and TCC of the ovary was made by histopathology and immunohistochemical studies (IHC).