Human and Toxoplasma gondii genetics and cellular/molecular interactions. Homo sapiens

The goal of this project is to infect relevant human host cells (MonoMac6, adult human neural progenitor (AHNP) cells, AHNP-derived neurons and human fibroblasts) with Toxoplasma gondii parasites of differing lineages to generate transcriptional mRNA and miRNA profiles. These datasets will allow the characterization of how genetically different parasites that cause distinct types of human toxoplasmosis alter the expression of protein-encoding and miRNA-encoding genes in both the human host and the parasite.