Brain Tumor Sequence Registration (BraTS-Reg) Challenge Dataset

Registration of longitudinal brain Magnetic Resonance Imaging (MRI) scans containing pathologies poses significant challenges due to substantial changes in tissue appearance. While general-purpose medical image registration techniques have advanced, they still lack the precision and reliability required for this complex task.

To address this gap, we organized the first-ever Brain Tumor Sequence Registration (BraTS-Reg) Challenge, which provides a public benchmark for deformable registration algorithms. The challenge focuses on establishing correspondences between pre-operative and follow-up scans of patients with diffuse brain gliomas. BraTS-Reg was conducted in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI) 2022 and the International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2022.

The challenge offers de-identified, multi-institutional, multi-parametric MRI scans, along with ground truth (GT) landmark points annotated by clinical experts at distinct anatomical locations across the temporal domain. To facilitate algorithm development, we are releasing the training data with GT annotations, while the validation data does not include GT annotations. During the testing phase, containerized algorithms were evaluated on hidden hold-out data.

BraTS-Reg serves as an active resource for research, with data and online evaluation tools available at https://bratsreg.github.io/. Quantitative evaluation and rankings during the challenge were based on key metrics, including Median Euclidean Error (MEE), Robustness, and the determinant of the Jacobian of the displacement field.