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Structure of RORgt in complex with a novel inverse agonist 1

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Protein Data Bank Japan2024-03-13 更新2026-03-21 收录
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Structure of RORgt in complex with a novel inverse agonist 1 Descriptor: N-[(1R)-1-(4-methoxyphenyl)-2-oxo-2-{[4-(trimethylsilyl)phenyl]amino}ethyl]-N-methyl-3-oxo-2,3-dihydro-1,2-oxazole-5-carboxamide, Nuclear receptor ROR-gamma Authors: Skene, R.J, Hoffman, I. Deposit date: 2017-09-20 Release date: 2018-01-03 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Discovery of orally efficacious ROR gamma t inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds. Bioorg. Med. Chem., 26, 2018
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2017-09-20
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