SenMayo transcriptomic senescence panel highlights glial cells in the ageing mouse and human retina

There is a growing need to better characterise senescent cells in the retina. The recently published SenMayo gene panel was developed to identify transcriptomic signatures of senescence across multiple organ systems, but the retina was not included. While other approaches have identified senescent cells in the retina, these have largely focused on experimental models in young animals. We therefore conducted a detailed transcriptomic analysis using single cell RNAseq to identify senescent cell populations in the mouse retina.当前学界对更精准表征视网膜内衰老细胞的需求日益迫切。近期发表的SenMayo基因检测组合（SenMayo gene panel）旨在识别多器官系统衰老的转录组特征，但未纳入视网膜组织。尽管已有其他研究方法成功识别出视网膜内的衰老细胞，但此类研究大多聚焦于幼年动物的实验模型。因此本研究采用单细胞RNA测序（single cell RNAseq）技术开展了详细的转录组分析，以鉴定小鼠视网膜内的衰老细胞群体。