Nuclear Phase Separation drives Acute Myeloid Leukemia
收藏NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP516259
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资源简介：
To investigate how nuclear condensates formed by NPM1c coordinate protein recruitment and promote chromatin binding in leukemia Overall design: We assessed chromatin binding of XPO1. NUP98, KMT2A, and MENIN in the context of NPM1c degradation, XPO1 inhibition, or MENIN inhibition using Cut-and-run sequencing Using an established OCI-AML3 cell line expressing an inducible degradation platform for NPM1c, we treated cells for 24hrs with dTAG-13, Eltanexor, or VTP50469 and performed Cut-and-run sequencing
创建时间：
2026-02-19
