Results of the meta-analysis.

IntroductionThe optimal intravenous fluid for kidney transplantation (KT) is still controversial. This meta-analysis aimed to compare the efficacy and safety of plasma-lyte solution (PL) versus saline (NS) in kidney transplantation.Materials and methodsA comprehensive search was conducted across four databases (PubMed, Embase, Web of Science, and the Cochrane Library) to identify relevant randomized controlled trials (RCTs) comparing plasma-lyte and saline in kidney transplantation. Risk of bias was assessed using the Cochrane RoB 2.0 tool. Meta-analyses of delayed graft function (DGF), creatinine levels, urine output, blood pH, bicarbonate, base excess, electrolytes, serum chloride, potassium and sodium immediately post-surgery were performed.ResultsTotally six randomized controlled studies with 1197 patients were included. In comparison to the NS group, the PL group exhibited a significantly lower incidence of DGF (OR: 0.66, 95% CI: 0.51 to 0.86, P = 0.002) and reduced serum chloride (MD: -8.87, 95% CI: -13.50 to -4.25, P = 0.0002) as well as serum sodium(MD: -1.08, 95% CI: -1.54 to -0.61, P ConclusionsThis meta-analysis compared the efficacy and safety between plasma-lyte and saline in kidney transplantation. Plasma-lyte reduced delayed graft function in kidney transplant compared to saline.Trial registrationPROSPERO (CRD42024588701).