Characterization of Protein Conformational Changes with Sparse Spin-Label Distance Constraints
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/Characterization_of_Protein_Conformational_Changes_with_Sparse_Spin_Label_Distance_Constraints/2479585
下载链接
链接失效反馈官方服务：
资源简介：
The combination of site-directed spin labeling with pulse
EPR distance
measurements can provide a moderate number of distance constraints
on the nanometer length scale for proteins in different states. By
adapting an existing algorithm (Zheng, W.; Brooks, B. R. Biophys.
J. 2006, 90, 4327) to the problem,
we address the question to what extent conformational change can be
characterized when the protein structure is known for one of the states,
whereas only a sparse set of distance constraints between spin labels
is available for the other state. We find that the type and general
direction of the conformational change can be recognized, while the
amplitude may be uncertain.
创建时间：
2016-02-20
