A morphological dataset of white blood cells from patients with four different genetic AML entities and non-malignant controls (AML-Cytomorphology_MLL_Helmholtz)

This dataset comprises four prevalent AML subtypes with defining genetic abnormalities and typical morphological features according to the WHO 2022 classification: (i) APL with PML::RARA fusion, (ii) AML with NPM1 mutation, (iii) AML with CBFB::MYH11 fusion (without NPM1 mutation), and (iv) AML with RUNX1::RUNX1T1 fusion, as well as a control group of healthy stem cell donors. A total of 242 peripheral blood smears from the Munich Leukemia Laboratory (MLL) database from the years 2009 to 2020 were digitized and consist of 99 - 500 automatically selected individual white blood cell images per patient.