Expression profiling of soleus muscle under the effect of simulated spaceflight

A distinct difference between spaceflight-induced muscle atrophy and other forms of atrophy is the additional effect of cosmic rays in outer space. To study spaceflight-induced muscle atrophy, we performed two ground-based models of microgravity in a low dose radiation environment and studied transcriptional changes in rat soleus muscle using microarray technology.航天诱导型肌肉萎缩与其他类型肌肉萎缩的显著区别在于，外层空间宇宙射线所带来的额外影响。为研究航天诱导型肌肉萎缩，我们构建了两种低剂量辐射环境下的地面微重力模型，并借助微阵列（microarray）技术分析了大鼠比目鱼肌的转录变化。