Transcriptional profiling of Candida albicans SC5314 grown on different carbon and nitrogen sources

Goal of this study was to investigate the metabolic adaptation of C. albicans to different carbon sources (malic acid, a-ketoglutarate, proline) and nitrogen sources (dipeptides). As a control medium with glucose as carbon source and ammonium sulfate as nitrogen source was used. Transcriptional profiles were compared after 4 h incubation at 37°C. Overall design: Candida albicans cells were cultivated in SD medium at 37°C until early log-phase was reached and transferred to the indicated medium, and incubated for 4 h at 37°C.