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Phosphomevalonate kinase; Leishmania donovani (HU3 strain)
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Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
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Simultaneous Arming and Structure/Activity Studies of Natural Products Employing O−H Insertions: An Expedient and Versatile Strategy for Natural Products-Based Chemical Genetics
The identification of “druggable” targets is an immediate opportunity and challenge in the post-genomic era. Natural products are enduring tools for basic cellular studies and leads for identifying me
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Crystal structure of Schistosoma mansoni purine nucleoside phosphorylase in complex with adenosine
Crystal structure of Schistosoma mansoni purine nucleoside phosphorylase in complex with adenosine Descriptor: ADENOSINE, DIMETHYL SULFOXIDE, Purine-nucleoside phosphorylase, ... Authors: Pereira, H.M
Protein Data Bank Japan2023-09-06 更新10
LDHU3_14.1610
Bifunctional NAD(P)H-hydrate repair enzyme; Leishmania donovani (HU3 strain)
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Global profiling of cancer cell recovery from therapy-induced stress reveals druggable vulnerabilities
Cancer cells survive therapy-induced stress, but how they resolve it is not clear. Using an integrated systems level approach we delineate the global mechanisms of cellular recovery from proteotoxic s
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