Coordinated changes of gut microbiome and lipidome differentiates nonalcoholic steatohepatitis (NASH) from isolated steatosis

Following 21-week of high fat diet (HFD)-feeding, obese mice were classified into two groups termed as isolated steatosis and NASH based on H&E staining of liver, total bacterial genomic DNA in cecum content were extracted. The gut microbiome were performed to identify key factors promoting the transition from isolated steatosis to NASH.