Although colorectal carcinoma development is well accepted as a step-wise and sequential process, it is commonly investigated using non-sequential adenoma and carcinoma samples. Here we compared molec
Abbreviations: HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; ISH, in-situ hybridization; SISH, silver in-situ hybridization; N, number.*HER2 positivity was defined as HER2
The p53 tumor suppressor gene is inactivated in human tumors by several distinct mechanisms. The best characterized inactivation mechanisms are: (i) gene mutation; (ii) p53 protein association with vi
