Palladacycle-Catalyzed Asymmetric Hydrophosphination of Enones for Synthesis of C*- and P*-Chiral Tertiary Phosphines
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https://figshare.com/articles/dataset/Palladacycle_Catalyzed_Asymmetric_Hydrophosphination_of_Enones_for_Synthesis_of_C_and_P_Chiral_Tertiary_Phosphines/2548774
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资源简介：
A highly reactive and stereoselective hydrophosphination
of enones
catalyzed by palladacycles for the synthesis of C*- and P*-chiral
tertiary phosphines has been developed. When Ph2PH was
employed as the hydrophosphinating reagent, a series of C*-chiral
tertiary phosphines were synthesized (C*–P bond formation)
in high yields with excellent enantioselectivities, and a single recrystallization
provides access to their enantiomerically pure forms. When racemic
secondary phosphines rac-R3(R4)PH were utilized, a series of tertiary phosphines containing both
C*- and P*-chiral centers were generated (C*–P* bond formation)
in high yields with good diastereo- and enantioselectivities. The
stereoelectronic factors involved in the catalytic cycle have been
revealed.
创建时间：
2016-02-22
