Iron-Catalyzed Regioselective Direct Oxidative Aryl–Aryl Cross-Coupling

Regioselective iron-catalyzed cross-dehydrogenative coupling
(CDC)
of two aromatic compounds using tert-BuOOH as oxidant
under mild conditions has been reported. The direct oxidative coupling
reaction is selective toward creation of a carbon–carbon bond
at the position ortho to the functional groups of
the substrates, completely preventing the homocoupled products. The
C–C bond-forming reaction makes the method versatile, leading
to functionalized 2,2′ -disubstituted biaryls.