Inhaled multi-walled carbon nanotubes-induced gene expression profile in rat lung (NM-403)

In this work we study the pulmonary toxicological properties of carbon nanotubes using molecular toxicological approache. For this, we exposed Sprague Dawley rats by nose-only inhalation 6 hours/day, 5 days/week for 4 weeks. Lung samples have been collected up to 180 days after the end of exposure and transcriptomics analysis were performed.本研究采用分子毒理学方法，探究碳纳米管的肺部毒理学特性。为此，我们通过仅经鼻吸入染毒的方式对斯普拉格-道利（Sprague Dawley）大鼠进行染毒，每日染毒6小时、每周染毒5天，持续4周。于染毒结束后最长180天的时段内采集肺组织样本，并开展转录组学（transcriptomics）分析。