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we present a public resource of functional genomic data from the dorsolateral prefrontal cortex (DLPFC; Brodmann areas 9 and 46) of 986 individuals from 4 separate brain banks, including 353 diagnosed with schizophrenia and 120 with bipolar disorder. The genomic data include RNA-seq and SNP genotypes on 980 individuals, and ATAC-seq on 269 individuals, of which 264 are a subset of individuals with RNA-seq. We have performed extensive preprocessing and quality control on these data so that the research community can take advantage of this public resource available on the Synapse platform at http://CommonMind.org.

我们在此公布一项公开功能基因组学数据集资源，其数据源自4个独立脑库的986名个体的背外侧前额叶皮层（dorsolateral prefrontal cortex, DLPFC；布罗德曼分区9和46区），其中353例被诊断为精神分裂症，120例为双相情感障碍患者。该数据集涵盖980名个体的RNA测序（RNA-seq）与单核苷酸多态性（SNP）基因型数据，以及269名个体的转座酶可及性测序（ATAC-seq）数据，其中264名个体同时具备RNA-seq数据。我们已对这批数据开展了全面的预处理与质量控制工作，以便科研界可利用该公开资源，相关资源可通过Synapse平台的http://CommonMind.org获取。