Crystal structure of human glutaminase in complex with inhibitor 4
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Crystal structure of human glutaminase in complex with inhibitor 4 Descriptor: 5,5'-butane-1,4-diylbis(1,3,4-thiadiazol-2-amine), Glutaminase kidney isoform, mitochondrial Authors: Thangavelu, K, Sivaraman, J. Deposit date: 2012-02-23 Release date: 2012-06-13 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
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2012-02-23
