Additional file 3: Table S3. of Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns

ENCODE and EZH2 transcription factor overlay significantly associated with regions of differential methylation in cancer tissue. A) Transcription factors enriched in the top 10,000 most significant CpGs found in gene regulatory regions with higher methylation levels in the tumor tissues. B) TCGA validation of transcription factors enriched in the top 10,000 most significant CpGs found within gene regulatory regions with higher methylation levels in the tumor tissues. C) Analysis of significant methylation sites overlaid with EZH2 binding data from an androgen-dependent (LNCaP) and an androgen-independent (LNCaP-abl) prostate cancer cell line. D) Transcription factors enriched in the top 10,000 most significant CpGs within gene regulatory regions with higher methylation in the benign-adjacent tissue. E) TCGA validation of transcription factors enriched in the top 10,000 most significant CpGs found within gene regulatory regions with higher methylation in the benign-adjacent tissue. (XLSX 45Â kb)