Additional file 4: Clusters detected by SweepCluster for chromosome 2 variants between EUR-AFR selected at a series of Fst cutoff (0.4, 0.43, 0.45, 0.5, 0.55, 0.6, 0.65, and 0.7).
1,232 SNPs with significant Fst scores (pB<8.6E−6, pE<0.001) were clustered into contiguous genomic regions of linkage disequilibrium. A cluster was defined as a collection of SNPs in a genomic region
Estimates of selection coefficient s under different models. p0 is the genome-wide mean of African average dosages; p1 is the peak African average dosage at MHC.
The FST-heterozygosity outlier approach has been a popular method for identifying loci under balancing and positive selection since Beaumont and Nichols first proposed it in 1996 and recommended its u
FA = favorable allele; FFA H_LNAE = frequency of the favorable alleles in the H_LNAE group; FFA L_LNAE = frequency of the favorable allele in the L_LNAE group.
