WHIM Gene Expression Data_Update Through WHIM 26

The objective of this microarray study was to obtain whole genome gene expression data from breast cancer, human to mouse xenograft models and from the primary cancer used for the xenograft, when possible. We also profiled these xenograft breast cancer tumors as they were passaged into additional mice. Whole Genome expression data allows us to monitor gene expression conservation and/or changes that occur from human to mouse, and from the initial mouse graft through subsequent passages. PAM50 molecular subtypes are also processed using the expression data. The xenografts provide in-vivo models for functional and therapeutic studies. 62 mRNA microarray experiments were completed for 19 different WU-BC (Washington University-Breast Cancer) lines which also had data from a patient biospy as well as multiple passages from a mouse xenograft. 2 tumors had data from mouse xenograft passages but no data from the patient biopsy. Each representative patient tumor sample and mouse xenograft passage was amplified, labeled, and co-hybridized with a reference sample.