Anthropometrics and quantitative metabolic traits of a total of 5,597 successfully genotyped middle-aged and treatment-naïve individuals from the Inter99 sample including the 4,239 glucose-tolerant individuals presented in Table 1.

Study participants are stratified according to rs2237895 genotypes of KCNQ1. P-values shown are for an additive genetic model and are adjusted for age, BMI and sex. incAUC, incremental area under the curve; HOMA-IR, homeostasis model assessment of insulin resistance; BIGTT-SI, BIGTT-insulin sensitivity; BIGTT-AIR, BIGTT acute insulin response.