Enrichment of imprinted genes in somatic stem cell populations from published gene expression studies.

Datasets from the Gene Expression Omnibus (GEO) that included stem cells together with a comparator population were used to examine enrichment for the IGN using Gene Set Enrichment Analysis (GSEA) with a custom imprinted-gene gene set. As originally defined [16], the IGN includes 16 genes, but for this analysis we also included additional imprinted genes that were specific to the LT-HSCs in our study [11]. This combined IGN-HSC list includes Asb4, Cdkn1c, Dcn, Dlk1, Gatm, Gnas, Grb10, Gtl2, H19, Igf2, Igf2r, Impact, Mest, Ndn, Nnat, Peg3, Peg10, Peg12, Plagl1, Ppp1r9a, Sgce, Slc22a3, Slc22a18, and Slc38a4.(a)The nominal P-value for all tests indicating 0.000 is