Genome Sequencing of Lung Cancer in European Americans and African Americans

The goal of this study is to compare the somatic mutation landscape between European Americans and African Americans. It includes various histological forms of lung cancer. In LUAD, we find increased prevalence of PTPRT and JAK2 mutations among African Americans. These proteins function in the same pathway and as such, this may be a new actionable target for lung cancer. We have also examined the landscape of copy number profiles in African Americans and European Americans.]]>
Exclusion criteria for eligibility included: being more than 24 months after initial cancer diagnosis, non-US resident, non-English speaking, residing in an institution such as a prison, nursing home or shelter, severely ill, or unable to give informed consent.]]>
Cases for this study were recruited from seven different hospitals in the Baltimore metropolitan area since 1998. The recruitment includes self-reported African American and European American participants.]]>