Differential expression of plasma miRNAs in immune thrombocytopenia

We investigated the expression profiles of plasma miRNAs in immune thrombocytopenia (ITP) patients. Peripheral blood plasma was used for Agilent miRNA expression microarray analysis to define miRNA profiles and to identify miRNAs with discriminatory levels for ITP and healthy controls. Results were further validated using quantitative realtime PCR on a larger cohort, enabling relative quantification of plasma miRNAs and defining miRNAs with diagnostic value for the disease. We analyzed expression profiles of plasma miRNAs from a total of individuals: 6 healthy controls and 10 ITP patients.