Diversity-Oriented Synthesis of Imidazo-Dipyridines with Anticancer Activity via the Groebke–Blackburn–Bienaymé and TBAB-Mediated Cascade Reaction in One Pot
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https://figshare.com/articles/dataset/Diversity-Oriented_Synthesis_of_Imidazo-Dipyridines_with_Anticancer_Activity_via_the_Groebke_Blackburn_Bienayme_and_TBAB-Mediated_Cascade_Reaction_in_One_Pot/9551807
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资源简介：
A facile
and metal-free one-pot protocol for the synthesis of fused
imidazopyridine scaffolds has been developed. This novel protocol
combines the Groebke–Blackburn–Bienaymé reaction
(GBBR) with a sequential TBAB-mediated cyclization cascade. Biological
evaluation demonstrated that compound 6a inhibits human
prostate cancer cell DU-145 proliferation with an IC50 of
1.6 μM. The molecular mechanism study indicates that 6a significantly suppresses the oncogenic Erk kinase phosphorylation
at 3 μM.
创建时间：
2019-07-30
