Data set for the paper entitled "CRISPR-enabled genetic screens identify synthetic lethal targets across frequently altered cancer drivers" by Desjardins, Bowlan, et al. (2026)

We undertook a series of genome-wide CRISPR screens using functionally validated isogenic cell lines and mapped SL interactions across 15 genetic alterations characteristic of diseases with high incidence and unmet clinical need: FBXW7, CCNE1, CDK12, ARID1A, KMT2D, DNMT3A, TET2, KEAP1, STK11, IDH1, SF3B1, SRSF2, U2AF1, chromosome 18q loss, and chromosome 13q loss. The data deposited here make the raw read count files available for all CRISPR screens conducted in the study.