AAgMarker

Human Serum Autoantigen Biomarker Resource (AAgMarker 1.0) is a free database that provides information of non-invasive serum autoantigen biomarker candidates identified from high-throughput autoantibody profiling projects. For basic search, autoantigen biomarkers are those desregulated autoantigens which could distinguish patients with diseases from healthy controls (AUC≥0.6, P value≤0.05) and be easily detected with high signaling rate (≥10%) in either group; Sensitivity, specificity and discriminative ability are also introduced to quantitatively evaluate the performance of biomarkers.人血清自身抗原生物标志物数据库（AAgMarker 1.0）是一款免费数据库，收录了高通量自身抗体谱分析项目中鉴定得到的非侵入性血清自身抗原候选生物标志物相关信息。在基础检索场景下，自身抗原生物标志物指可区分疾病患者与健康对照的失调自身抗原（受试者工作特征曲线下面积（Area Under the Curve，AUC）≥0.6，P值≤0.05），且在两类群体中均能以≥10%的高信号检出率被便捷检测；同时引入灵敏度、特异性与判别能力等指标，以定量评估生物标志物的性能表现。

搜集汇总

背景与挑战

背景概述

AAgMarker是一个提供非侵入性血清自身抗原生物标志物候选物信息的免费数据库，包含通过高通量自身抗体分析项目识别的生物标志物，并采用严格的筛选标准和性能评估指标。