Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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https://www.ncbi.nlm.nih.gov/sra/SRP474703
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资源简介：
Osimertinib is a third-generation covalent epidermal growth factor receptor (EGFR) inhibitor in treating non-small cell lung cancer. Herein we report that clinical achievable dose of osimertinib selectively induced apoptosis of CD34+ leukemia stem/progenitor cells, but not CD34- cells in EGFR-negative acute myeloid leukemia (AML) and chronic myeloid leukemia (CML).
创建时间：
2023-12-01
