five

Mouse ear tissue at 2 days post immunization

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE230920
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Gene expression analysis using nCounter immunology panel for profiling among naïve controls and immunized treatment samples. We explored the interplay between type-I IFNs and the development of host protective Th1 immunity in mice immunized with LmCen-/- parasites and challenged with L. donovani parasites and show that downregulation of IRF7 mediated production of IFN-α/β is critical for the induction of protective immunity. In this study, using transcriptomics, we present differential gene exression to evaluate early immune response conditions upon immunization.
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2023-05-01
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