miRNA profiles in livers with different mass deficits after partial hepatectomy and miR-106b~25 cluster accelerating hepatocyte proliferation in rats

To query the relationship between miRNA profiles and deficits in liver mass after PH and the miRNAs linked to liver regeneration, we compared the miRNA expression profile after 2/3 PH, a standard procedure that leads to robust DNA synthesis, with that after 1/3 PH, a procedure that causes minimal replication. The patterns and dynamics of miRNA profiles after PH were featured, providing a rich resource of miRNAs underlying mechanisms of liver regeneration.为探究微小RNA（miRNA）表达谱与2/3部分肝切除术（partial hepatectomy, PH）后肝体积缺损的关联，以及与肝脏再生相关的miRNA，本研究将2/3 PH（该标准术式可诱导旺盛的DNA合成）后的miRNA表达谱，与1/3 PH（该术式仅引发极微弱的细胞增殖）后的表达谱进行了对比。本研究对PH术后miRNA表达谱的模式与动态变化进行了系统表征，为阐明肝脏再生潜在机制的相关miRNA提供了宝贵的研究资源。