Cannabis Extracts Effects on Metabolic Parameters and The Link to Gut Microbiome Composition in Mice fed High-Fat Diet-Induced. mice gut microbiome

the mice were divided into two groups which were fed with normal diet (ND) or high fat diet (HFD). Twelve weeks of HFD-regime resulted in a significant increase in BW despite a decrease in food intake by this group. In-creased BW was accompanied with increased insulin resistance as indicated by higher fasting blood glucose levels and reduced glucose tolerance. Following the next 8 weeks (weeks 13-20) HFD-fed mice were subdivided into four groups according to weather and which cannabis extract was supplemented to their diet, namely CN1, CN2 or CN6