KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

To investigate the role of KMT2D in the lung squamous cell carcinoma (LUSC), we established the Kmt2d WT and Kmt2d Mut cells Comparative gene expression profiling analysis of RNA-seq data for Kmt2d KO Kmt2d WT cells Comparative gene expression profiling analysis of RNA-seq data Kmt2d KO and Kmt2d WT organoids and tumors Profiling the histone modification H3K4me1 and H3K4me3 in Kmt2d KO and Kmt2d WT cells Profiling the histone modification H3K27ac in Kmt2d KO and Kmt2d WT cells Profiling the chromatin accessibility using ATAC-seq in Kmt2d KO and Kmt2d WT cells