Gene expression profile of different cell types in the tumor microenvironment of MOC1 tumors treated with Smyd3 anti-sense oligonucleotides (ASOs).

We used scRNA-seq to assess the differential effect of Smyd3 ASOs on the transcriptomic profile of different cell types in the TME of MOC1 tumors. Overall design: MOC1 tumors were implanted in the flank of C57BL/6 mice were treated with control (n=3) or Smyd3 ASOs (n=3) for 18 days. Tumors were surgically resected, digested into single-cell suspensions and scRNA-seq was conducted.