SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis

Triple-negative breast cancer (TNBC) has a relatively aggressive biological behavior and poor outcome. Our published study showed that PAI-1 could induce the migration and metastasis of TNBC cells. However, the underlying mechanism by which PAI-1 regulates TNBC metastasis has not been addressed. Using microarray analysis of lncRNA expression profiles, we identified a lncRNA SOX2-OT, which is by induced by PAI-1 and could function as an oncogenic lncRNA in TNBC. We treated MDA-MB-231 cells with or without recombinant human PAI-1 or PAI-1 small-molecule inhibitor PAI-039, then used microarray analysis to obtain the lncRNAs expression profiles. Biological replicates: 3 control replicates, 3 transfected replicates.