Teusink1998_Glycolysis_TurboDesign

This is the model described in the article:
The danger of metabolic pathways with turbo design

Teusink B, Walsh MC, van Dam K, Westerhoff HV Trends Biochem. Sci.
1998 May; Volume: 23 (Issue: 5 ): 162-9 9612078
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Abstract:

Many catabolic pathways begin with an ATP-requiring activation step, after which further metabolism yields a surplus of ATP. Such a 'turbo' principle is useful but also contains an inherent risk. This is illustrated by a detailed kinetic analysis of a paradoxical Saccharomyces cerevisiae mutant; the mutant fails to grow on glucose because of overactive initial enzymes of glycolysis, but is defective only in an enzyme (trehalose 6-phosphate synthase) that appears to have little relevance to glycolysis. The ubiquity of pathways that possess an initial activation step, suggests that there might be many more genes that, when deleted, cause rather paradoxical regulation phenotypes (i.e. growth defects caused by enhanced utilization of growth substrate).
The model represents the wild-type cell: 'guarded' glycolysis, which is the inhibition of the HK module by hexose monophosphate. The model reproduces figures 3c and 3d of the reference publication.
To reproduce unguarded glycolysis, set parameter wild_type to '0'.
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