TOPMed MESA multi-ancestry transcriptome prediction models
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下载链接：
https://zenodo.org/record/14338881
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资源简介：
This Zenodo file collection includes three developed transcriptome prediciton models with funtionally informed variants (FIVs) by using TOPMed MESA multi-ancestry participants with TOPMed Freeze 8 whole-genome sequencing (WGS) data and RNA-seq data from peripheral blood mononuclear cells (PBMCs). These prediction models can be used for transcriptome-wide association study (TWAS) analysis by integrating with GWAS summary statistics.
EN-FM: Elastic Net with Fine-Mapped variants;
PUMICE: Prediction Using Models Informed by Chromatin conformation and Epigenomics; 3D genomic data and epigenomic annotation from EBV-transformed lymphocytes were used to construct PUMICE models;
PUMICE-FM: PUMICE with Fine-Mapped variants.
创建时间：
2024-12-09
