In this study, a predictive model based GPR will be developed and evaluated on the basis of its ability to accurately estimate the influence of six physical parameters on D eff .
Voltage sensitive calcium channels are not listed because they use the same parameters and equations as Wolf et al. [16], but using m instead of mx for CaL1.2, CaN, CaR, and CaT. V = voltage, scale =
Activation and steady-state inactivation parameters were calculated by data fitting to Boltzmann functions (see Methods). V1/2 is the voltage for half-maximal activation or steady-state inactivation a
