Additional file 2: Table S1. of Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components

The let-7 expression profilesof the matched head and neck normal and tumor tissues. Correlation coefficients for individual let-7 isoforms relative to COP9 genes are shown. Asterisks: p < 0.05. Table S2. To support the result of Table 3, 2 additional normal head and neck tissues were included to calculate correlation of expressions among the COP9 genes. Correlation coefficients of COP9 genes versus COPS5 (rCOPS5) were determined from randomly selected 44 tumor specimens from the entire pool of 511. The calculations were repeated for 10,000 times to obtain their mean and standard deviation (sd) values, which were used to compare the difference from rCOPS5 of normal tissues. Table S3. RNAseq data from young (30 specimens) and elderly patients (31 specimens) were used to calculate the correlation coefficients among the COP9 genes. Table S4. 14 normal oral cavity tissues were pooled based on the TCGA clinical data, and the correlation coefficients and their p values for COPS5 were calculated as described in the main article. Table S5. Data based on the 13 normal tongue tissues were pooled based on the clinical data in the TCGA database, and the correlation coefficients and their p values for COPS5 were calculated. Table S6. 11 normal tissues from smokers were pooled based on the clinical data in the TCGA database, and the correlation coefficients and their p values for COPS5 were calculated. Table S7. Nh: number of genes found within 1 Mbp of each COP9 gene; mean, sd, p and q values were determined as described in Materials and Methods. Table S8. ES for COP9 genes for all KEGG pathways. Table S9. ES for COP9 genes for the oxidative phosphorylation pathway. (XLS 80Â kb)