IL-17 Signaling in Steatotic Hepatocytes and Macrophages Promotes Alcoholic Liver Disease-induced Hepatocellular Carcinoma [II]

IL-17A is a tumor-promoting cytokine, which critically regulates inflammatory responses in myeloid cells, and cholesterol synthesis in steatotic hepatocytes in experimental model of alcohol-induced HCC. Therefore, IL-17A may be a potential therapeutic target for EtOH-induced HCC patients. IL-17RAdHEPand IL-17RAF/F mice (C57BL/6, 2 weeks old)were injected i.p. with DEN (25mg/kg body weight, Sigma). DEN-challenged mice were subjected to isocaloric liquid EtOH feeding, or chow-fed for 18 weeks.